India, Sept. 14 -- Week 2 of the NFL season has several notable injury updates that could affect games across the league.

San Francisco will be without quarterback Brock Purdy, who is sidelined with both a shoulder issue and turf toe.

Head coach Kyle Shanahan said Purdy could miss between two and five weeks, meaning Mac Jones will start in his place. Receiver Jauan Jennings is questionable with a shoulder problem, while left tackle Trent Williams is also uncertain with a knee injury.

For New York, rookie wideout Malik Nabers has been managing back pain but practiced fully by the end of the week and is expected to play against Dallas. Left tackle Andrew Thomas, however, is doubtful due to a foot injury.

In Buffalo, running back James C...