International Clinical Trial: Neuroprotective effect and mechanism of dexmedetomidine pretreatment on postoperative cognitive dysfunction in elderly patients with major non-cardiac surgery: a prospective randomized controlled study based on electroencephalogram (EEG) monitoring

Geneva, March 23 -- International Clinical Trials Registry received information related to the study (ChiCTR2600120360) titled 'Neuroprotective effect and mechanism of dexmedetomidine pretreatment on postoperative cognitive dysfunction in elderly patients with major non-cardiac surgery: a prospective randomized controlled study based on electroencephalogram (EEG) monitoring' on March 12.

Study Type: Interventional study

Study Design: Parallel

Primary Sponsor: Zhengzhou Central Hospital Affiliated to Zhengzhou University

Condition: postoperative cognitive dysfunction

Intervention: Dextromethorphan group:Received a venous loading dose of dexmedetomidine (0.5 µg/kg within 10 minutes) followed by a maintenance infusion (0.2-0.7 &...