Clinical Trial: Volumetric Adaptive SBRT Versus Conventional Accelerated Radiation Therapy for Early-Stage Glottic Cancer

U.S., Oct. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07895745) titled 'Volumetric Adaptive SBRT Versus Conventional Accelerated Radiation Therapy for Early-Stage Glottic Cancer' on Oct. 19.

Brief Summary: This non-inferiority trial will compare conventional long-course accelerated fractionation radiation therapy (AF-RT) with volumetric adaptive stereotactic body radiation therapy (SBRT) in patients with early-stage (cT1-2N0M0) glottic squamous cell carcinoma. Participants will be randomized in a 1:2 ratio to receive either AF-RT (Arm A) or adaptive SBRT (Arm B).

The primary objective is to determine whether adaptive SBRT provides non-inferior local control compared with AF-RT in patients with early-st...