U.S., June 17 -- ClinicalTrials.gov registry received information related to the study (NCT07651293) titled 'Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression' on June 02.
Brief Summary: Clinical depression is a common and disabling condition characterised by persistent low mood and loss of interest that interferes with daily functioning. Serotonin is a key brain neurotransmitter involved in mood regulation, and a leading theory proposes that depression is associated with impaired serotonin function (the serotonin deficiency hypothesis), which underpins the use of selective serotonin reuptake inhibitors (SSRIs) as first-line antidepressant treatments. However, the strength and specificity of the link between serotoni...