U.S., March 10 -- ClinicalTrials.gov registry received information related to the study (NCT07459101) titled 'UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4' on Nov. 17, 2025.
Brief Summary: This study builds on the results of prior studies (UNITED and UNITED-3). The goal of UNITED-4 is to test whether an adaptive radiation therapy (RT) therapy approach ('dose painting'), with reduced margins, impacts approach in participants with glioblastoma impacts local control compared to standard non-adaptive RT approach. The main questions of the study are to see how this adaptive RT approach with reduced margins compares to standard RT in terms of:
* Local control
* Overall and progression-free survival
* Patterns of f...