Clinical Trial: UNDERSTANDING THE T-CELL AND B-CELL RECEPTOR REPERTOIRE IN CHILDREN AND YOUNG ADULTS WITH ANTI-DRUG ANTIBODIES AGAINST PEG ASPARAGINASE

U.S., March 31 -- ClinicalTrials.gov registry received information related to the study (NCT07499336) titled 'UNDERSTANDING THE T-CELL AND B-CELL RECEPTOR REPERTOIRE IN CHILDREN AND YOUNG ADULTS WITH ANTI-DRUG ANTIBODIES AGAINST PEG ASPARAGINASE' on March 24.

Brief Summary: The aim of this sub study is to identify biomarkers in children and young adults with ALL with hypersensitivity to PEG-asparaginase.

Evidence strongly implicates humoral immunity in asparaginase immunogenicity with neutralizing antibodies18. Asparaginase is a bacterial enzyme not naturally present in the human body, and therefore highly immunogenic. Upon administration, antigen-presenting cells internalize and present fragments of the enzyme to naive T cells, driving t...