U.S., March 17 -- ClinicalTrials.gov registry received information related to the study (NCT07473895) titled 'Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Split-Face Study' on March 11.
Brief Summary: Acne vulgaris is one of the most common dermatological conditions affecting adolescents and young adults. It results from multiple pathogenic factors, including increased sebum production, follicular hyperkeratinization, colonization by Cutibacterium acnes, and inflammation. Topical retinoids such as adapalene are widely used as first-line therapy; however, they may cause irritation and are not always effective in all patients. Recently, topical antiandrogen therapies such as spironolactone have gained attentio...