Clinical Trial: Tissue Modeling in Systemic Sclerosis Using Induced Pluripotent Stem Cells (iPSCs)

U.S., June 17 -- ClinicalTrials.gov registry received information related to the study (NCT07650565) titled 'Tissue Modeling in Systemic Sclerosis Using Induced Pluripotent Stem Cells (iPSCs)' on May 18.

Brief Summary: The objective of the study is to establish an in vitro model using iPSCs to test the hypotheses developed.

The primary objective is to generate, via the SAFE-IPS platform, 8 iPSC lines derived from blood samples taken from:

* Two patients with severe/diffuse SSc with multi-organ involvement (with anti-SCl-70 autoantibodies)

* Two of their healthy close relatives

* Two patients with uncomplicated SSc with localized involvement (with non-SCl-70 autoantibodies)

* Two of their healthy close relatives

These 8 cell lines wil...