U.S., July 16 -- ClinicalTrials.gov registry received information related to the study (NCT07705789) titled 'The Role of interferOn and Complement in SecondAry thRombotic micrioangiOpathy' on June 19.
Brief Summary: Study rationale: Viral infections, such as CMV, are a risk factor for TA-TMA (transplantation-associated TMA). Viral infections increase interferon (IFN) levels and high IFN levels are associated with thrombotic microangiopathy (TMA). IFNs contribute to TMA pathogenesis through suppression of VEGF transcription. Disruption of the VEGF signalling pathway in the kidney is associated with TMA.
Primary objective: To determine the association between IFN levels and the development of biopsy-proven or clinically diagnosed TA-TMA.
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