U.S., May 23 -- ClinicalTrials.gov registry received information related to the study (NCT07602764) titled 'The Effects of Nitrate-Rich Mouthwash on Vascular Tone' on Dec. 29, 2025.
Brief Summary: High blood pressure (hypertension) is a major risk factor for cardiovascular disease. One important contributing factor to high blood pressure is reduced availability of nitric oxide (NO). Therefore, NO is an important molecule in maintaining healthy blood vessel function.
Dietary nitrate, found in leafy greens, can serve as an alternative source of nitric oxide in the body. After ingestion, nitrate is converted to nitrite by bacteria residing in the oral cavity. Nitrite can subsequently be converted to NO when swallowed. Therefore, this nitrate...