U.S., Sept. 9 -- ClinicalTrials.gov registry received information related to the study (NCT07807306) titled 'Targeting Muscle-Bone Crosstalk Through Physical Therapy in Cancer Cachexia' on Aug. 27.
Brief Summary: This study investigates the role of a structured physical therapy (PT) program in managing cancer-induced cachexia (CIC) by targeting muscle-bone crosstalk. Cancer-induced cachexia leads to severe muscle wasting, systemic inflammation, and functional decline, which often limits treatment tolerance and quality of life. While exercise is known to attenuate protein breakdown and modulate muscle-derived cytokines (myokines), its specific impact on muscle-bone signaling in non-metastatic cancer patients undergoing chemotherapy remains ...