Clinical Trial: Study on the Mechanism of ADC Drug Evaluation Based on Immune Co-culture of Lung Cancer Organoids

U.S., May 29 -- ClinicalTrials.gov registry received information related to the study (NCT07610616) titled 'Study on the Mechanism of ADC Drug Evaluation Based on Immune Co-culture of Lung Cancer Organoids' on May 12.

Brief Summary: A case-control study was conducted to evaluate the efficacy and mechanism of action of antibody-drug conjugates (ADCs) in lung cancer, utilizing patient-derived organoid (PDO)-immune co-cultures. Focusing on HER2-positive and TROP2-positive non-small cell lung cancer (NSCLC) cases, ADC candidates were screened for in vitro activity based on organoid-immune interaction models.

Key assessments included:

Tumor killing efficiency, assessed by dose-response relationships; Drug internalization (cellular uptake), as...