U.S., March 5 -- ClinicalTrials.gov registry received information related to the study (NCT07449832) titled 'Sperm Epigenome in Hodgkin Lymphoma' on Dec. 03, 2025.
Brief Summary: Cancer treatments can have long-term effects on fertility. In men, scientific studies suggest that the process of sperm formation (spermatogenesis) may be disrupted even years after recovery, with potential consequences not only for fertility but also for the health of offspring. The effects of chemotherapy on sperm quality, particularly on DNA packaging (chromatin) and the epigenome, remain poorly understood. Therefore, further in-depth studies are needed to determine whether a history of cancer and chemotherapy treatment may impact the health of children fathere...