Clinical Trial: Severe Pediatric Respiratory Syncytial Virus Infections Occurring in the Era of Antiviral Prophylaxis

U.S., Oct. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07893652) titled 'Severe Pediatric Respiratory Syncytial Virus Infections Occurring in the Era of Antiviral Prophylaxis' on Oct. 19.

Brief Summary: Hospitalization for RSV lower respiratory tract infections (LRTI) still occurs, including in infants having received nirsevimab/clesrovimab or born to mothers vaccinated with Abrysvo.

We hypothesize that pediatric patients hospitalized for RSV LRTIs occurring in the era of large use of prophylaxis, could be, at least in part, explained by virological factors (emergence/selection of variants with decreased susceptibility to prophylaxis) and/or immunological factors (inherited immune deficiency, presence o...