Clinical Trial: Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model

U.S., June 5 -- ClinicalTrials.gov registry received information related to the study (NCT07625475) titled 'Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model' on May 22.

Brief Summary: Temporal summation (TS) and offset analgesia (OA) are widely used psychophysical endpoints in pain research that index different components of central nociceptive processing. While crossover designs are commonly used in experimental pain studies to reduce between-participant variability, the design-stability of these endpoints under repeated testing during experimental sensitisation is not well characterised. This study compared the design-stability of mechanical TS (Sumscore) and offset analgesia magnitude (OffA) in a two-period, vehicle...