U.S., April 23 -- ClinicalTrials.gov registry received information related to the study (NCT07545616) titled 'Screening for Biomarkers of Osteonecrosis of the Femoral Head' on April 15.
Brief Summary: Osteonecrosis of the femoral head (ONFH) presents a rapidly progressive natural disease course. Femoral head collapse may occur within two years, ultimately necessitating total hip arthroplasty and imposing a heavy medical and economic burden on patients. Early intervention can significantly improve the long-term prognosis of ONFH. However, due to the lack of validated biomarkers for early diagnosis, the early diagnostic rate remains low, with a primary diagnostic rate of merely 68.43% at the first visit, accompanied by a high rate of misdiag...