Clinical Trial: rhTNK-tPA for Acute Ischemic Stroke Under Simplified Imaging in the Extended Time Window

U.S., May 27 -- ClinicalTrials.gov registry received information related to the study (NCT07606807) titled 'rhTNK-tPA for Acute Ischemic Stroke Under Simplified Imaging in the Extended Time Window' on April 22.

Brief Summary: The PEARL-SIMPLIFIED trial is a multicenter, prospective, randomized controlled, open-label, blinded-endpoint study. It aims to evaluate the efficacy and safety of intravenous tenecteplase (TNK) in patients with acute ischemic stroke (AIS) presenting in the extended 4.5-24 hour window, using a simplified imaging selection strategy based solely on non-contrast CT (NCCT).

Study Start Date: Aug. 01, 2026

Study Type: INTERVENTIONAL

Condition: Acute Ischemic Stroke

Intervention: DRUG: Tenecteplase (rhTNK-tPA) (0.25 m...