Clinical Trial: PyroEVs/PLIN3 Mediate Lipid Droplet-Mitochondrial Coupling in Sepsis Endothelial Injury

U.S., July 28 -- ClinicalTrials.gov registry received information related to the study (NCT07727265) titled 'PyroEVs/PLIN3 Mediate Lipid Droplet-Mitochondrial Coupling in Sepsis Endothelial Injury' on July 13.

Brief Summary: Objective: To investigate the correlation of PyroEVs and PLIN3 with the severity and prognosis of sepsis patients.

Participants: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of Zhongda Hospital affiliated with Southeast University, as well as healthy volunteers.

Inclusion Criteria:

1. Presence of confirmed or suspected infection;

2. Sequential Organ Failure Assessment (SOFA) score increase >= 2 points from baseline;

3. Signed informed consent. Exclusion Criteria: A...