U.S., April 17 -- ClinicalTrials.gov registry received information related to the study (NCT07532824) titled 'Proton-Based Total Marrow Irradiation for Allogeneic Transplantation in High-Risk AML/MDS' on Feb. 12.
Brief Summary: This is an open-label, single-center, non-randomized phase I/II pilot study evaluating proton-based Total Marrow Irradiation (TMI) as part of the conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adult patients with high-risk or relapsed/refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). These patients have an unfavorable prognosis with standard conditioning approaches.
Participants will receive a standard conditioning regimen consisting of eithe...