Clinical Trial: Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder

U.S., July 30 -- ClinicalTrials.gov registry received information related to the study (NCT07734701) titled 'Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder' on July 08.

Brief Summary: This study will evaluate whether pregnenolone is an effective treatment for adults with Alcohol Use Disorder (AUD) and Major Depressive Disorder (MDD). Participants will be randomly assigned to receive either pregnenolone or placebo for 12 weeks in a double-blind study. Researchers will assess alcohol consumption, alcohol craving, depressive symptoms, and anxiety symptoms throughout treatment. The study will also use magnetic resonance imaging (MRI) to examine how pregnenolone affects brain circuits involved in addiction and moo...