U.S., April 8 -- ClinicalTrials.gov registry received information related to the study (NCT07516119) titled 'Predicting Pre-dementia' on March 31.
Brief Summary: The goal of this observational study is to learn how well a multimodal "Progression and Risk" (PR) model can predict and stage early mild cognitive impairment (MCI) due to Alzheimer's disease in cognitively normal or very mildly impaired ApoE4-positive adults aged 55 and older. The main questions it aims to answer are:
Can a prespecified proteogenomic PR model accurately predict conversion from cognitively normal (CN) or very mildly impaired status to pTau217-positive MCI Stage I within 24 months in ApoE4-positive adults?
Does adding digital monitoring features (e.g., sleep, act...