U.S., April 14 -- ClinicalTrials.gov registry received information related to the study (NCT07525661) titled 'Perioperative Hyperoxia vs Normoxia Biomarker Trial' on March 30.
Brief Summary: This single-center randomized interventional study evaluated the biological effects of two perioperative oxygen strategies in adults undergoing elective laparoscopic lower abdominal surgery under standardized general anesthesia. Participants were assigned to receive either normoxia (FiO2 0.35) or hyperoxia (FiO2 0.80) after intubation and throughout the intraoperative period. The study assessed perioperative changes in circulating biomarkers related to pulmonary epithelial stress, endothelial glycocalyx injury, oxidative stress, and inflammation, toget...