U.S., April 9 -- ClinicalTrials.gov registry received information related to the study (NCT07516626) titled 'Patient-Derived Organoids to Functionally Characterize Chemotherapy Resistance in Breast Cancer' on April 01.
Brief Summary: This prospective observational study aims to functionally characterize chemotherapy resistance in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. Despite standard molecular classification, significant heterogeneity in treatment response exists, and the biological mechanisms underlying chemoresistance remain incompletely understood.
In this study, patient-derived organoid (PDO) models will be established from tumor tissues obtained during routine clinical care. These three-dim...