U.S., Oct. 23 -- ClinicalTrials.gov registry received information related to the study (NCT07887906) titled 'Pain Sensitivity and Pruritus of Peripheral Nerves' on Oct. 15.
Brief Summary: Previous research has demonstrated that itch and pain share several underlying neural pathways and signaling molecules. Understanding these common mechanisms is important for developing more effective therapeutic strategies targeting both sensations. Mepyramine, an antihistamine, has been reported to exert effects on both itch and pain perception. In this study, we aim to investigate these effects using established experimental models of itch and pain. Itch will be induced using histamine, a naturally occurring substance in the human body, and spicules fr...