U.S., March 11 -- ClinicalTrials.gov registry received information related to the study (NCT07462299) titled 'NUDT15/TPMT Multi-gene Guided 6-MP Dosing in Childhood ALL Maintenance Therapy' on March 02.
Brief Summary: This is a prospective, single-center clinical study to evaluate the safety and efficacy of a personalized 6-mercaptopurine (6-MP) dosing strategy guided by NUDT15 and TPMT genotypes in children with Acute Lymphoblastic Leukemia (ALL) during maintenance therapy. The study compares this gene-guided strategy with historical controls to assess if it reduces the incidence of Grade >=3 neutropenia and infection events.
Study Start Date: Feb. 20
Study Type: INTERVENTIONAL
Condition:
Childhood Acute Lymphoblastic Leukemia
Interv...