Clinical Trial: Neoadjuvant SHR-1701 Plus Chemoradiotherapy for Locally Advanced Rectal Cancer

U.S., March 18 -- ClinicalTrials.gov registry received information related to the study (NCT07478731) titled 'Neoadjuvant SHR-1701 Plus Chemoradiotherapy for Locally Advanced Rectal Cancer' on Dec. 12, 2025.

Brief Summary: The goal of this clinical trial is to learn if SHR-1701 combine with chemoradiotherapy works to treat severe CRC.

Participants will take:

Induction: SHR-1701 combined with CAPOX for one cycle. Radiotherapy: Short-course radiotherapy (SCRT) (25Gy/5F). Consolidation: SHR-1701 combined with CAPOX for five cycles, after which the subjects undergo TME surgery.

Study Start Date: Dec. 20, 2025

Study Type: INTERVENTIONAL

Condition: CRC (Colorectal Cancer)

Intervention: DRUG: SHR-1701 neoadjuvant

Induction: SHR-1701 comb...