U.S., Sept. 5 -- ClinicalTrials.gov registry received information related to the study (NCT07803952) titled 'NAC in Spontaneous Bacterial Peritonitis' on Aug. 31.
Brief Summary: Spontaneous bacterial peritonitis (SBP) is one of the most serious infectious complications of liver cirrhosis and ascites. It affects approximately 10-30% of hospitalized patients with decompensated cirrhosis and carries an in-hospital mortality of 20-40% despite appropriate antimicrobial therapy (1,2). SBP results from bacterial translocation across the intestinal mucosa together with cirrhosis-associated immune dysfunction, leading to impaired bacterial clearance and exaggerated systemic inflammation (3). Current international guidelines recommend immediate empi...