Clinical Trial: Multi-omics Profiling of Relapsed Extranodal Natural Killer (NK)/T-cell Lymphoma

U.S., Nov. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07920757) titled 'Multi-omics Profiling of Relapsed Extranodal Natural Killer (NK)/T-cell Lymphoma' on Oct. 27.

Brief Summary: This retrospective observational study characterises the tumour immune microenvironment and clonal architecture of relapsed or refractory extranodal NK/T-cell lymphoma (ENKTCL). Archival tumour tissue and blood samples collected during routine care are profiled by single-cell RNA sequencing, T-cell and B-cell receptor repertoire sequencing, whole-exome sequencing, and spatial transcriptomics. The study examines how immune and stromal cell states, clonal composition and spatial organisation relate to response to programmed cell...