Clinical Trial: Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest

U.S., Oct. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07895771) titled 'Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest' on Oct. 19.

Brief Summary: Most patients resuscitated from out-of-hospital cardiac arrest (OHCA) remain comatose on hospital admission and are routinely managed with continuous sedation. Sedation facilitates temperature control, but deep and prolonged sedation is associated with longer mechanical ventilation, delirium, infections and delayed awakening. It is unknown whether minimizing sedation increases secondary hypoxic-ischemic brain injury.

This single-centre, open-label, randomized non-inferiority trial will compare a minimal sedation str...