U.S., Feb. 24 -- ClinicalTrials.gov registry received information related to the study (NCT07428148) titled 'Lattice-Based Radiotherapy and Chemoimmunotherapy for Oropharyngeal Squamous Cell Carcinoma' on Feb. 17.
Brief Summary: This single-arm Phase I/II trial evaluates induction chemoimmunotherapy combined with lattice radiotherapy (LRT) in patients with non-low risk oropharyngeal squamous cell carcinoma and primary tumor >=3 cm or primary tumor and pathologic lymph node >=3 cm in longest dimension. BOIN12 adaptive dose-finding will guide dose across two anatomical cohorts-primary-tumor only (P) and primary + largest involved node (PN)-with a total target accrual of about 60 evaluable patients.
Dose-limiting toxicity is monitored separa...