U.S., Feb. 26 -- ClinicalTrials.gov registry received information related to the study (NCT07432373) titled 'Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural Infection' on Feb. 19.
Brief Summary: Pneumonia, thought to be the chief aetiological process in the development of pleural space infection, is defined as an infection of the lung parenchyma with an estimated annual incidence rate of 5-11 cases per 1000 population, with around 50,000 hospital admissions in the U.K. per year. Parapneumonic effusions caused by an infection of the pleural membranes occur in 40-57% of cases of pneumonia. A variable percentage (10-20%) of parapneumonic effusions progresses to empyema (pus) and/or abscess formation (encapsulation)...