U.S., May 29 -- ClinicalTrials.gov registry received information related to the study (NCT07611058) titled 'Inflammatory Response in Children Suffering From Tethered Cord' on Oct. 13, 2023.
Brief Summary: Embryologic phenomenons that lead to dysraphisms are known, but pathophysiology remains questioned. It is supposed not to be a simple mechanistic dysfunction, and other biological phenomenons are implied in spinal cord damaging. Two main hypothesis are that manual deformation of the cells and mitochondrial membranes lead to energy deficiency and blood flow changes. On the other hand, considering traumatic spinal cord injuries (SCI), inflammation has been shown to have dramatic effects on spinal cord function and physiology. Indeed, all es...