Clinical Trial: Individualized fMRI-guided TMS for Depression

U.S., Sept. 5 -- ClinicalTrials.gov registry received information related to the study (NCT07804459) titled 'Individualized fMRI-guided TMS for Depression' on Aug. 31.

Brief Summary: The goal of this clinical trial is to learn how transcranial magnetic stimulation (TMS) affects brain circuits involving the subgenual anterior cingulate cortex (sgACC) in adults with depression. The main questions it aims to answer are:

* Can brain responses in the sgACC before treatment predict improvement in depressive symptoms following TMS?

* Does a 6-week course of active TMS, compared with sham TMS, change brain responses in the sgACC?

* Are changes in sgACC responses during treatment associated with changes in depressive symptoms?

Researchers will ...