U.S., June 4 -- ClinicalTrials.gov registry received information related to the study (NCT07624734) titled 'Impact of the Intraoperative Use of Amines in Breast Cancer Surgery on Tumor Recurrence' on May 19.
Brief Summary: Adrenergic receptors (alpha and beta) are expressed on breast cancer cells, and their stimulation has been shown in experimental studies to promote tumor proliferation and metastasis. Conversely, observational data suggest that beta-blockers may have a protective effect on cancer recurrence. During mastectomy, adrenergic agonists such as catecholamines (e.g., ephedrine, phenylephrine, norepinephrine) and other agents (e.g., clonidine) are frequently used intraoperatively to maintain hemodynamic stability, potentially act...