U.S., March 24 -- ClinicalTrials.gov registry received information related to the study (NCT07487259) titled 'Impact of the Early Life Virome Development on Bronchopulmonary Dysplasia in Preterm Neonates' on March 17.
Brief Summary: Bronchopulmonary dysplasia (BPD) is the most frequent respiratory complication in extremely preterm infants. It leads to significant mortality and long-term morbidity. The pathophysiology of BPD is multifactorial, involving inflammation and oxidative stress due to neonatal exposures such as mechanical ventilation and infections.
Previous studies have highlighted the role of respiratory bacterial microbiota in BPD development, with causal effects having been demonstrated in murine models. Moreover, the gut-lung...