Clinical Trial: High-Intensity Interval Training and Monocyte Epigenetic Adaptation After Detraining

U.S., Aug. 19 -- ClinicalTrials.gov registry received information related to the study (NCT07771075) titled 'High-Intensity Interval Training and Monocyte Epigenetic Adaptation After Detraining' on Aug. 13.

Brief Summary: This randomized, work-matched training-detraining-rechallenge study evaluated whether repeated high-intensity interval training produces persistent functional and epigenetic adaptations in human monocytes. Eighty healthy physically inactive adults aged 18-30 years were randomly assigned in a 2:2:1 ratio to high-intensity interval training (HIIT), moderate-intensity continuous training (MCT), or a non-training control group. HIIT and MCT completed 6 weeks of supervised cycling training matched for external mechanical work,...