U.S., Nov. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07934407) titled 'HBOT for Perianal Crohn's Disease' on Nov. 08.
Brief Summary: Background Perianal fistulae are among the most disabling complications of Crohn's disease, causing significant morbidity, impaired quality of life, and substantial healthcare utilisation. Despite advances in biologic and surgical therapies, many patients experience persistent fistula drainage and fail to achieve durable healing.
Tissue hypoxia is a key regulator of intestinal inflammation and impaired wound healing in inflammatory bowel disease. Hyperbaric oxygen therapy (HBOT) increases tissue oxygenation, promotes angiogenesis, modulates inflammatory pathways, and may...