Clinical Trial: Gut Microbiota and Amino Acid Metabolism in Post-CPB Delayed Neurocognitive Recovery

U.S., Nov. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07936929) titled 'Gut Microbiota and Amino Acid Metabolism in Post-CPB Delayed Neurocognitive Recovery' on Nov. 08.

Brief Summary: Delayed neurocognitive recovery (dNCR) is a common neurological complication in adult patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Emerging evidence suggests that CPB-associated hypoperfusion and perioperative stress remodel the gut microbiome and impair intestinal barrier integrity, which may contribute to neuroinflammation and cognitive decline via the gut-brain axis. This prospective observational cohort study aims to investigate the longitudinal trajectories of the gut metagenome (specificall...