U.S., March 11 -- ClinicalTrials.gov registry received information related to the study (NCT07459816) titled 'Genomic of CONgenital Sideroblastic Anemias' on Nov. 17, 2025.
Brief Summary: Congenital sideroblastic anemias (CSA) are a group of rare disorders characterized by abnormal iron utilization during erythropoiesis, leading to mitochondrial iron overload, the formation of ring sideroblasts, and ineffective erythropoiesis resulting in anemia. Ring sideroblasts are erythroid precursors that contain non-heme iron deposits in their mitochondria, forming a distinctive ring-like pattern around the nucleus. Mitochondria are double membrane organelle provide a large amount of energy for cellular activities, by the process of oxidative phospho...