Clinical Trial: Emulation of the KEYNOTE177 Trial Using Specialty Oncology Electronic Health Records Databases

U.S., Oct. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07861347) titled 'Emulation of the KEYNOTE177 Trial Using Specialty Oncology Electronic Health Records Databases' on Sept. 29.

Brief Summary: This observational trial emulation aims to reproduce the KEYNOTE-177 trial (NCT02563002) using real-world specialty oncology electronic health record data and to assess the concordance between the original and emulated treatment effect estimates for overall survival (OS). KEYNOTE-177 was a phase III, open-label, randomized trial comparing first-line pembrolizumab with 5-fluorouracil-based chemotherapy, with or without bevacizumab or cetuximab, in patients with MSI-H or dMMR metastatic colorectal cancer.

Study S...