U.S., April 24 -- ClinicalTrials.gov registry received information related to the study (NCT07546669) titled 'Efficacy of Zoster Vaccination in Glioblastoma Patients' on April 16.
Brief Summary: In modern practice a trimodality treatment has emerged as standard of care for histologically confirmed glioblastoma.
We hypothesize that the additional vaccination against herpes zoster, after surgical resection followed by irradiation therapy and chemotherapy of patients with glioblastoma will lead to a superior local control, overall and progression free survival. In an additional experimental setting based on patient preference the immunological effectiveness of the adoptive transfer of autologous polyclonal cytomegalovirus (CMV) specific T ce...