U.S., June 25 -- ClinicalTrials.gov registry received information related to the study (NCT07666789) titled 'Efficacy of Islet Re-transplantation After Failure of Beta-cell Replacement' on June 09.
Brief Summary: Islet transplantation and pancreas transplantation are established therapeutic options for selected individuals with type 1 diabetes experiencing severe glycemic instability and recurrent hypoglycemia. Although these approaches significantly improve glycemic management and quality of life, long-term graft survival remains limited, with a progressive decline in beta-cell function over time.
The clinical benefit-risk profile of islet re-transplantation after graft failure remains poorly defined, and outcomes following repeat islet ...