Clinical Trial: Efficacy and Safety of HA35 Gel Nighttime Occlusive Application for TMD Pain

U.S., May 14 -- ClinicalTrials.gov registry received information related to the study (NCT07584642) titled 'Efficacy and Safety of HA35 Gel Nighttime Occlusive Application for TMD Pain' on April 28.

Brief Summary: This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of nighttime occlusive application of 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with temporomandibular joint disorder (TMD). Eligible participants will apply HA35 gel to the TMJ area nightly under occlusive conditions for 8-12 hours. The primary objectives are to assess rapid pain relief and muscle over-tension reduction at 60 seconds and 12 hours after application. Safety and local tolerability will be ev...