Clinical Trial: Efficacy and Safety of Cyclophosphamide in Amyotrophic Lateral Sclerosis

U.S., Sept. 23 -- ClinicalTrials.gov registry received information related to the study (NCT07834450) titled 'Efficacy and Safety of Cyclophosphamide in Amyotrophic Lateral Sclerosis' on Sept. 11.

Brief Summary: The goal of this clinical trial is to learn whether cyclophosphamide (CTX) combined with standard treatment can slow disease progression in adults with amyotrophic lateral sclerosis (ALS). It will also evaluate the safety and tolerability of CTX. The main questions it aims to answer are:

1. Does CTX combined with standard treatment reduce the decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores over 48 weeks compared with standard treatment alone?

2. What medical problems and side effects do participants have while re...