U.S., Nov. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07936227) titled 'Effect of Sirolimus on Oocyte Quality in Women Undergoing IVF' on Nov. 09.
Brief Summary: Poor oocyte (egg before maturation) quality remains a major barrier to IVF success, particularly in women with prior cycles demonstrating low oocyte maturity, poor fertilization rates, or suboptimal embryo development. Preclinical and early clinical evidence suggests that the mTOR pathway plays a critical role in oocyte and follicular development, and pharmacologic inhibition with sirolimus (also known as rapamycin), may improve oocyte competence by adjusting granulosa cell function and follicular aging processes.
We propose a multicenter pilo...