U.S., April 23 -- ClinicalTrials.gov registry received information related to the study (NCT07546058) titled 'Effect of Local Subperiosteal Zoledronic Acid Injection on the Survival of Orthodontic Miniscrews' on April 09.
Brief Summary: Background: Orthodontic miniscrews are widely used as temporary anchorage devices; however, failure remains a clinical concern. Bisphosphonates may enhance bone stability, but evidence on their local application is limited.
Objective: To evaluate the effect of local subperiosteal zoledronic acid (ZA) injection on miniscrew survival and peri-miniscrew inflammation.
Materials and Methods: This triple-blind, split-mouth randomized controlled trial included 68 patients requiring bilateral maxillary premolar e...