Clinical Trial: Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes

U.S., May 23 -- ClinicalTrials.gov registry received information related to the study (NCT07604883) titled 'Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes' on May 18.

Brief Summary: This prospective observational study aims to identify and preliminarily validate molecular biomarkers, including microRNAs and metabolites, for early differentiation between Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). The study will enroll up to 100 PD patients, 50 suspected APS patients, and 50 healthy controls. Participants will undergo clinical assessments and provide blood, urine, and stool samples at baseline and after 12-18 months. Molecular analyses (microRNA profiling, metabolomics, RNA-seq, and microbiome ...