Clinical Trial: Development of Low-Intensity Focused Ultrasound for Post Traumatic Brain Injury Depression

U.S., Sept. 19 -- ClinicalTrials.gov registry received information related to the study (NCT07828483) titled 'Development of Low-Intensity Focused Ultrasound for Post Traumatic Brain Injury Depression' on Sept. 14.

Brief Summary: The goal of this clinical trial is to learn about evaluate the safety, tolerability, and feasibility of MRI-guided LIFU targeting the sgACC in Veterans with post-traumatic brain injury depression. The main questions it aims to answer are:

1. the safety, tolerability, and feasibility of MRI-guided LIFU.

2. Evaluate preliminary antidepressant efficacy.

3. Characterize target engagement using multimodal neuroimaging and electrophysiology.

4. Identify imaging and electrophysiological biomarkers that predict treatm...