U.S., May 27 -- ClinicalTrials.gov registry received information related to the study (NCT07605884) titled 'Denys-Drash Syndrome and Risk of Post-transplant Lymphoproliferative Disorder' on April 20.
Brief Summary: Denys-Drash syndrome is a rare genetic disorder of childhood characterized by nephrotic syndrome, nephroblastomas, and genital developmental abnormalities. These children present with rapidly progressive renal failure, leading to kidney transplantation at a median age of 3.6 years. In a study of the French cohort of patients with Denys-Drash syndrome, a high risk of lymphoproliferative syndrome was observed (20%). This frequency is significantly higher than in the general transplant population (4%).
The aim of the study is to e...