Clinical Trial: Comparison of Citrate and Heparin Anticoagulation During Postdilution Hemodiafiltration

U.S., June 2 -- ClinicalTrials.gov registry received information related to the study (NCT07618858) titled 'Comparison of Citrate and Heparin Anticoagulation During Postdilution Hemodiafiltration' on May 16.

Brief Summary: This randomized crossover clinical trial will compare regional citrate anticoagulation (RCA) and standard heparin anticoagulation (HA) during postdilution hemodiafiltration (HDF) in chronic dialysis patients with end-stage kidney disease.

The primary aim of the study is to evaluate biocompatibility during HDF by measuring markers of complement activation (C3a), platelet activation (PF4), and coagulation activation (thrombin-antithrombin complex, TAT).

Secondary aims include comparison of solute removal efficiency, incl...